Symbol
Name
ID

Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
MGI:95808

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Interictal epileptiform activity	Absent speech	Self-injurious behavior	Intellectual disability, severe	Sleep abnormality	Delayed fine motor development	Seizure
Disease(s) Associated with GRIA1
autosomal recessive intellectual developmental disorder 76

Mouse Phenotypes

nervous system phenotype

abnormal dendrite morphology

abnormal spinal cord morphology

abnormal nervous system electrophysiology

impaired ability to fire action potentials

impaired synaptic plasticity

abnormal excitatory postsynaptic potential

abnormal glutamate-mediated receptor currents

reduced AMPA-mediated synaptic currents

abnormal long-term potentiation

reduced long-term potentiation

abnormal miniature excitatory postsynaptic currents

decreased prepulse inhibition

absent long-term depression

Availability

Mouse Genotype

Gria1^em1(IMPC)H/Gria1^em1(IMPC)H

Gria1^{em1(IMPC)Hmgu}/Gria1^{em1(IMPC)Hmgu}

Gria1^tm1Rlh/Gria1^tm1Rlh

Gria1^tm1Rsp/Gria1^tm1Rsp

Gria1^tm2Rlh/Gria1^tm2Rlh

Gria1^tm4Rlh/Gria1^tm4Rlh

Gria1^tm7Rlh/Gria1^tm7Rlh

Gria1^tm2Rsp/Gria1^tm2Rsp
Tg(Pvalb-cre)1Mony/0 (conditional)

Gria1^tm2Rsp/Gria1^tm2Rsp
Tg(Slc6a3-icre)9075Gsc/0 (conditional)

Gria1^tm2Rsp/Gria1^tm2Rsp (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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